About Us
CREST-2 is a multi-center randomized clinical study sponsored by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health.
Physicians want to find a better way to prevent strokes. CREST-2 is designed to compare three different methods of stroke prevention to find the safest and most effective treatment for patients with narrowing of their carotid arteries. The stroke prevention methods include intensive medical management alone compared to intensive medical management in combination with a procedure to reopen the carotid artery in the neck (called revascularization) for treatment of plaque buildup. The two procedures available in this study are carotid endarterectomy (en-dar-ter-EK-ta-mee) and carotid artery stenting. All participants will receive intensive medical management to help control their risk factors for stroke.
The physicians chosen to participate in CREST-2 were selected because they have previous experience and are skilled at performing the procedures. They have completed a rigorous credentialing process by CREST-2 and are approved by the CREST-2 Executive Committee.
CREST-2 will enroll a maximum of 2,480 participants at over 150 medical centers across the United States, Canada, Spain, Israel, and Australia.
Physicians want to find a better way to prevent strokes. CREST-2 is designed to compare three different methods of stroke prevention to find the safest and most effective treatment for patients with narrowing of their carotid arteries. The stroke prevention methods include intensive medical management alone compared to intensive medical management in combination with a procedure to reopen the carotid artery in the neck (called revascularization) for treatment of plaque buildup. The two procedures available in this study are carotid endarterectomy (en-dar-ter-EK-ta-mee) and carotid artery stenting. All participants will receive intensive medical management to help control their risk factors for stroke.
The physicians chosen to participate in CREST-2 were selected because they have previous experience and are skilled at performing the procedures. They have completed a rigorous credentialing process by CREST-2 and are approved by the CREST-2 Executive Committee.
CREST-2 will enroll a maximum of 2,480 participants at over 150 medical centers across the United States, Canada, Spain, Israel, and Australia.
CREST-2 Executive Committee
Thomas G. Brott, MD
Principal Investigator Clinical Coordinating Center Mayo Clinic, Jacksonville, FL |
George Howard, DrPH
Principal Investigator Statistical & Data Coordinating Center University of Alabama, Birmingham, AL |
James F. Meschia, MD
Co-Principal Investigator Clinical Coordinating Center Mayo Clinic, Jacksonville, FL |
Brajesh K. Lal, MD
Co-Principal Investigator Vascular Imaging Core Lab and CREST-2 Registry, University of Maryland Medical Center, Baltimore, MD |
Kevin M. Barrett, MD, Co-Investigator for Recruitment, Mayo Clinic, Jacksonville, FL
Robert D. Brown, Jr., MD, Co-Investigator Publications, Mayo Clinic, Rochester, MN
Seemant Chaturvedi, MD, Co-Investigator Collaborations, University of Miami Miller School of Medicine, Miami, FL
Marc Chimowitz, MD, Co-Investigator Medical Management Core, Medical University of South Carolina, Charleston, SC
Bart M. Demaerschalk, MD, Co-Investigator Site Selection & Management, Mayo Clinic, Phoenix, AZ
Virginia J. Howard, PhD, Co-Investigator Statistical and Data Coordinating Center, University of Alabama, Birmingham, AL
John Huston, III, MD, Co-Investigator Brain Imaging, Mayo Clinic, Rochester, MN
Ronald M. Lazar, PhD, Co-Investigator Cognitive Function, Columbia University Medical Center, NYC, NY
Wesley S. Moore, MD, Co-Investigator Surgery, University of California Los Angeles, CA
Richard T. Benson, MD, PhD, NINDS, Program Director
Gary S. Roubin, MD, PhD, Co-Investigator, Intervention, Cardiovascular Associates of the Southeast, Birmingham, AL
Tanya N. Turan, MD, Co-Investigator Medical Management Core, Medical University of South Carolina, Charleston, SC
Jenifer H. Voeks, PhD, Co-Investigator, Biostatistics (unblinded & non-voting), Medical University of South Carolina, Charleston, SC
Lloyd J. Edwards, PhD, Co-Investigator, Biostatistics, University of Alabama, Birmingham, AL
Robert D. Brown, Jr., MD, Co-Investigator Publications, Mayo Clinic, Rochester, MN
Seemant Chaturvedi, MD, Co-Investigator Collaborations, University of Miami Miller School of Medicine, Miami, FL
Marc Chimowitz, MD, Co-Investigator Medical Management Core, Medical University of South Carolina, Charleston, SC
Bart M. Demaerschalk, MD, Co-Investigator Site Selection & Management, Mayo Clinic, Phoenix, AZ
Virginia J. Howard, PhD, Co-Investigator Statistical and Data Coordinating Center, University of Alabama, Birmingham, AL
John Huston, III, MD, Co-Investigator Brain Imaging, Mayo Clinic, Rochester, MN
Ronald M. Lazar, PhD, Co-Investigator Cognitive Function, Columbia University Medical Center, NYC, NY
Wesley S. Moore, MD, Co-Investigator Surgery, University of California Los Angeles, CA
Richard T. Benson, MD, PhD, NINDS, Program Director
Gary S. Roubin, MD, PhD, Co-Investigator, Intervention, Cardiovascular Associates of the Southeast, Birmingham, AL
Tanya N. Turan, MD, Co-Investigator Medical Management Core, Medical University of South Carolina, Charleston, SC
Jenifer H. Voeks, PhD, Co-Investigator, Biostatistics (unblinded & non-voting), Medical University of South Carolina, Charleston, SC
Lloyd J. Edwards, PhD, Co-Investigator, Biostatistics, University of Alabama, Birmingham, AL